After reading each of the four peer-reviewed articles you selected, use the Matrix Worksheet template to analyze the methodologies applied in each of the four peer-reviewed articles. Your analysis should include the following:

• The full citation of each peer-reviewed article in APA format.
• A brief (1-paragraph) statement explaining why you chose this peer-reviewed article and/or how it relates to your clinical issue of interest, including a brief explanation of the ethics of research related to your clinical issue of interest.
• A brief (1-2 paragraph) description of the aims of the research of each peer-reviewed article.
• A brief (1-2 paragraph) description of the research methodology used. Be sure to identify if the methodology used was qualitative, quantitative, or a mixed-methods approach. Be specific.
• A brief (1- to 2-paragraph) description of the strengths of each of the research methodologies used, including reliability and validity of how the methodology was applied in each of the peer-reviewed articles you selected.

Over the course of the next eight weeks, we will be examining concepts related to nursing research and the translation of evidence to practice. To help you better understand the process, you will be identifying a practice issue for nurse practitioners. You will develop a PICOT question associated with the issue, find evidence to support a change in practice, and present your recommendations for change to your peers. This week, we will work on helping you refine your area of interest so that you will be able to develop a concise question for next week’s assignment. You are encouraged to use the area of interest you chose for the project in previous class.

Select an issue in nurse practitioner (NP) practice that is of interest to you and in which you would like to see a practice change occur. Conduct a review of literature to see what is currently known about the topic. In 1-2 paragraphs, describe the scope and relevance of the issue and your recommended change. Provide reference support from at least two outside scholarly sources to support your ideas. Please pick something you can do as a NP in your practice that is patient focused. Your intervention needs to relate to a measurable patient health outcome. Please avoid anything that would require a policy or law change, such as full-practice authority. Burnout and satisfaction surveys also are not appropriate topics as they are not patient centered. 

Post a disucssion post on the topic of evidence-based practice in the health care organization where you practice (psychiatric hospital). Drawing on your understanding of EBP and your firsthand observations within your organization, include the following content in your blog:

• Briefly describe one specific example of evidence-based practice that produced/is producing significant patient outcomes. Or, if you are lacking examples, describe a recent patient experience that might have been improved through application of evidence-based practice. Explain your reasoning. Note: To maintain confidentiality, do not refer to individuals by name or with identifying details.
• Evaluate the overall application of evidence-based practice within your health care organization, including conditions that support it or roadblocks to overcome. Explain your reasoning, including how you have arrived at your conclusions.
• Describe how you can advocate for application of evidence-based practice within your health care organization.
• please provide at least 3 references

Trends in Informatics

Discussion

Purpose

This week's graded discussion topic relates to the following Course Outcomes (COs).

Preparing the Discussion

· Discussions are designed to promote dialogue between faculty and students, and students and their peers. In discussions students:

· Demonstrate understanding of concepts for the week

· Integrate outside scholarly sources when required

· Engage in meaningful dialogue with classmates and/or instructor

· Express opinions clearly and logically, in a professional manner

· Use the rubric on this page as you compose your answers.

· Best Practices include:

· Participation early in the week is encouraged to stimulate meaningful discussion among classmates and instructor.

· Enter the discussion often during the week to read and learn from posts.

· Select different classmates for your reply each week.

Discussion Question

This is the week to really see where technology and healthcare are connecting. Select ONE of the following trends and discuss your understanding of this trend in healthcare and its potential impact on your practice as a nurse. What are the legal, privacy, and ethical considerations of this trend? (Everyone attempt to choose a different topic so that we will learn about the many advancements in technology).

· Nanotechnology

· Consumer health informatics (CHI)

· Social media healthcare applications

· Health-focused wearable technology

· eHealth

· Artificial Intelligence

· Simulation

· Computerized provider order entry (CPOE)

· Bar Code Medication Administration (BCMA)

· Creative measures in healthcare for use with 3D printers

· Smart Pumps

· Smart Rooms

· Robotics in healthcare

· Mobile technology in outpatient care

· Web-based tools and software technology

· Risk Management tools

· Chatbots or Bots in healthcare

· Telenursing

· Telemedicine

· Telepharmacy

· Telerehabilitation

· Teleconsultation

· Telehospice

· Technology advancement from your clinical practice

· Palm Vein Technology

· Microchip use in healthcare

· Optical head-mounted computer glasses (Google Glass)

· Smart hospital beds

· EBOOK to use for one citation:

· https://bookshelf.vitalsource.com/reader/books/9781323903148/epubcfi/6/492%5B%3Bvnd.vst.idref%3DP7001015544000000000000000002CB2%5D!/4/2%5BP7001015544000000000000000002CB2%5D/2/2%5BP7001015544000000000000000002CB3%5D/7:6%5B%20In%2Cter%5D

· email:
[email protected]

· Pwd: Leroyismyhero1#

·

let me know if you cannot have access to the ebook

·
Prof needs one citation from the ebook and one external citation

· At least 2 citations

My main post in response to each of the following: 

1. Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.

The agonist-to-antagonist spectrum of action is a concept used in psychopharmacology to describe the various ways to interact with receptors to control the neurotransmitter activities in the nervous system. These interactions can have different effects influence behavior and mood. To understand this spectrum, it’s important to grasp the concepts of agonists, antagonists, partial agonists, and inverse agonists:

Agonists are substances that activate or stimulate a receptor when they bind to neurotransmitters, leading to an increase in neurotransmitter activity. For example, drugs that function as serotonin agonists can mimic the effects of serotonin in the brain, potentially resulting in improvements in mood and anxiety.

Antagonists are substances that bind to receptors but do not activate them. Instead, they block or inhibit the action of neurotransmitters. Antagonists can be used to reduce the effects of certain neurotransmitters. For example, Naloxone is an antagonist. It is an opioid receptor antagonist. it rapidly reverses the effects of opioids, such as heroin, and morphine by competitively binding to opioid receptors. This action can rapidly reverse the life-threatening effects of opioid overdose in emergencies. it can be a life-saving intervention when used promptly.

Partial agonists are substances that activate a receptor to a lesser extent compared to a full agonist. They have a moderate effect on receptor activity. Partial agonists are often used in psychopharmacology to achieve a more subtle or balanced effect. For example, a partial serotonin agonist might provide some mood improvement without inducing extreme mood swings.

Inverse agonists are substances that produce the opposite effect of an agonist. They bind to a receptor and reduce its baseline activity. They can turn down the activity of a receptor even in the absence of an agonist. Depending on the receptor system targeted, inverse agonists may have a sedative or calming effect, which can be useful in treating conditions associated with over-activity in specific neurotransmitter systems.

1. Compare and contrast the actions of g couple proteins and ion-gated channels.

G protein-coupled receptors (GPCRs) and ion-gated channels are both essential components of neurotransmission in the nervous system. There are two distinct types of cell membrane proteins involved in signal transduction and the regulation of cellular responses. They play different roles in the process. They both are activated by the binding of neurotransmitters to their receptor sites on the postsynaptic neuron.

GPCRs work indirectly by activating intracellular signaling pathways. When a neurotransmitter binds to a GPCR, it triggers a cascade of events that involves the activation of G proteins. These G proteins then interact with other signaling molecules, leading to various intracellular responses. GPCRs can regulate a wide range of cellular responses, including changes in gene expression, modulation of enzyme activity, and second messenger production. They have a broad and diverse range of functions.

Ion-gated channels, also known as ligand-gated ion channels, work directly by allowing the flow of ions across the cell membrane upon neurotransmitter binding. When a neurotransmitter binds to the channel’s receptor site, the channel opens, allowing ions to pass through, which can result in changes in the membrane potential and cellular excitability. Their function is more focused on altering the electrical properties of the neuron.

GPCRs are versatile and can modulate various intracellular pathways, while ion-gated channels directly control ion flow and cellular excitability. The choice between these mechanisms depends on the specific needs of the synaptic signaling and the desired cellular response.

1. Explain how the role of epigenetics may contribute to pharmacologic action.

Epigenetics involves alterations in gene expression or cellular phenotype. Epigenetic modifications can influence how genes are turned on or off, and these modifications can be influenced by pharmacological agents. Epigenetic modifications, such as DNA methylation and histone modifications, can impact the accessibility of genes to the cellular transcriptional machinery. Pharmacological agents can influence these epigenetic marks, either directly or indirectly, to regulate gene expression. Epigenetic changes can affect the expression of enzymes involved in drug metabolism. Understanding and harnessing the epigenetic aspects of drug action can lead to more effective and personalized therapeutic interventions.

1. Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.

As a Psychiatric Mental Health Nurse Practitioner (PMHNP), comprehending the implications of psychopharmacologic actions can profoundly shape my approach to prescribing medications for patients. The PMHNP’s knowledge of psychopharmacology plays a vital role in improving patient outcomes.

Imagine a patient, with a history of major depressive disorder. The patient has tried multiple antidepressant medications over the years with limited success and is currently experiencing a severe depressive episode with significant impairment in her daily life. As a PMHNP, I have learned psychopharmacology would be well-versed in the mechanisms of action of different antidepressant classes. For example, I would know that selective serotonin reuptake inhibitors (SSRIs) work by increasing the availability of serotonin in the brain by inhibiting its reuptake. I would also be aware that other classes like serotonin-norepinephrine reuptake inhibitors (SNRIs) and atypical antidepressants target different neurotransmitters.

By tailoring the medication choice to patient-specific needs, monitoring for side effects, and maintaining open communication, I can increase the likelihood of a successful treatment outcome for a patient’s depression.

Reference:

Mental Health TV. (2022, Oct 7).  Psychopharmacology-Module fourLinks to an external site. [Video]. YouTube.https://www.youtube.com/watch?v=46Ioy6SSta4&t=89sLinks to an external site.

Mental Health TV. (2022, Oct 7).  Psychopharmacology-Module five [Video]. YouTube. https://www.youtube.com/watch?v=1ynTQB59KW0&t=16s

Stahl, S. M. (2021). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (5th Ed.) Cambridge University Press.

The University of British Columbia. (n. d.). Neuroanatomy videosLinks to an external site.. http://neuroanatomy.ca/videos.htmlLinks to an external site.